I was curious about form of thousands of replication bubbles during DNA Replication. Do they form simultaneously or one by one? How long does it take for 1 replication bubble to be formed?
Campbell says eukaryotes may have hundreds to a few thousand bubbles, but does not cite a time to completion or a time to form one bubble. The process would require several enzymes to unzip the DNA and then hold it open, the application of RNA primase, the attachment of DNA polymerase to both ends and some bond making with nucleotides on both sides and at both ends of the bubble.
I think the bubbles can form both simultaneously or one by one. Many bubbles may form simulataneously along the DNA strand. But I don't know how long that takes...